3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

HRID 433540

反応式

HRID 433540 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH:14]([CH3:16])[CH3:15]

参加物

3

反応物 2

HCID 1454243,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

生成物 1

HCID 22894975N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

実験手順

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-Butyl Ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

出典と根拠

ORDレコード
ord-9ce02f93550240f3aae07095c15bee15
出典データセット
uspto-grants-2003_12
特許番号
US06667305B1

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