2-Methylimidazole → 2-(3,4-Dichloro-phenyl)-4-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride
反応式
Cl.[Cl:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH:5]=1.[CH3:18][C:19]1[NH:20][CH:21]=[CH:22][N:23]=1>>[ClH:2].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2[CH:5]=[C:4]([CH2:3][N:20]3[CH:21]=[CH:22][N:23]=[C:19]3[CH3:18])[CH:9]=[CH:8][N:7]=2)[CH:15]=[CH:14][C:13]=1[Cl:16]参加物
3
実験手順
The title compound, MS: m/e=317.0 (M+) was obtained as a beige solid (51% yield) by the reaction of 4-chloromethyl-2-(3,4-dichloro-phenyl)-pyridine hydrochloride (1:1) with 2-methylimidazole, using sodium hydride and triethylamine as base followed by formation of the hydrochloride salt.
出典と根拠
- ORDレコード
- ord-85a4753bd5b4412ba2723be4e01406c2
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667335B2
反応ノート
読み込み中…