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Triethylamine → 1,1-Dimethylethyl (2S)-4-({2-chloro-4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phenylmethyl (2S)-4-[(4-bromophenyl)methyl]-2-methyl-1-piperazine Carboxylate | HCID 25224210 | — |
| 反応物 | (S)-tert-butyl 2-methylpiperazine-1-carboxylate hydrochloride | HCID 45072182 | — |
| 反応物 | Methyl (3-chloro-4-formylphenyl)acetate | HCID 59520437 | — |
| 生成物 | 1,1-Dimethylethyl (2S)-4-({2-chloro-4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 67128047 | — |
反応手順
The title compound was prepared from methyl (3-chloro-4-formylphenyl)acetate (Epple, R. et al., PCT Int. Appl. WO2005116000) and 1,1-dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate hydrochloride using a method similar to that described for D6 with the addition of triethylamine (1.1 eq) to the reaction mixture and a reaction time of ˜3 days.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536182B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-e9595488509d4501862848e21dae7740 |
| 出典メモ | uspto-grants-2013_09 |