HCID 23444959、化合物 → Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-

HRID 433613ノート

反応式

HRID 433613 の反応式
[F:1][C:2]([C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:6]=1[F:14])([F:4])[CH3:3]>CO>[F:4][C:2]([C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[F:14])([F:1])[CH3:3]

参加物

3

反応物 1

HCID 23444959HCID 23444959、化合物

生成物 1

HCID 23445006Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-(1,1-difluoro-ethyl)-1-fluoro-4-nitro-benzene (10.4 g, 50.6 mmol) in methanol (200 ml) palladium on carbon (10%, 4 g) was added and the resulting mixture was hydrogenated for 2 h at 20° C. After filtration of the catalyst the solvent was evaporated to yield the title compound as a yellow semi solid mass. (8.5 g, 96%). MS: m/e=175 (M+).

後処理

  1. filtrationAfter filtration of the catalyst the solvent
  2. customwas evaporated

出典と根拠

ORDレコード
ord-f6cfa3ece53e4f2e990e07bf26b4eaf4
出典データセット
uspto-grants-2003_12
特許番号
US06667335B2

反応ノート

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