Boron, trifluoro(methanol)-, (T-4)- → HCID 86584267、化合物

HRID 433727

反応式

HRID 433727 の反応式
CO.B(F)(F)F.C([NH:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=O)C>>[NH2:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

参加物

3

反応物 2

HCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 86584266HCID 86584266、化合物

生成物 1

HCID 86584267HCID 86584267、化合物

実験手順

Into a boron trifluoride methanol complex methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

後処理

  1. temperaturethe mixture is heated
  2. concentrationThereafter, the reaction solution is concentrated
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-33db2df52e6946c8b20f6fd6038ad6ce
出典データセット
uspto-grants-2003_12
特許番号
US06667413B2

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