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Hydrochloric Acid → 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 18756272 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid | HCID 6484101 | 96.2% |
反応手順
A solution of 4-methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole (2.20 g, 8.84 mmol), MeOH (25 ml), and 2N NaOH (8.8 ml) was heated at 50° C. overnight (19 h). The reaction was cooled to room temperature, diluted with H2O, and acidified (2N HCl) to less than pH 3. The mixture was extracted with EtOAc (twice) and the combined extracts were washed (brine), dried (MgSO4), filtered, and concentrated to give the title compound (1.88 g, 96%). This material was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06670373B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-e39a911cdc174001b9a03a0ff5720557 |
| 出典メモ | uspto-grants-2003_12 |