Hydrochloric Acid → [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride

HRID 434300

反応式

C(OC([N:8]1[C@@H:12]([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)[CH2:11][O:10]C1(C)C)=O)(C)(C)C.Cl>C(O)C>[ClH:27].[NH2:8][C@H:12]([CH2:11][OH:10])[CH2:13][N:14]1[CH2:15][CH2:16][CH:17]([C:20]([C:21]2[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=2)=[O:28])[CH2:18][CH2:19]1

参加物

実験手順

(S)-4-[4-(4-chloro-benzoyl)-piperidin-1-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.68 g, 1.55 mmol) is added to a solution of hydrogen chloride in ethanol (5 ml, 5.5M). The reaction mixture is stirred at ambient temperature for 1 hour, then evaporated to dryness to afford [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride. [MH] 297.0.

後処理

customevaporated to dryness

出典と根拠

ORDレコード: ord-713c0094f74b43459937b20cdfdf2805
出典データセット: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06670379B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート