Acetyl chloride → 2-Acetoxy-1-(4-acetylphenyl)propane

HRID 434372

反応式

HRID 434372 の反応式
[C:1]([O:4][CH:5]([CH3:13])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[C:18](Cl)(=[O:20])[CH3:19]>ClC(Cl)C>[C:1]([O:4][CH:5]([CH3:13])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:18](=[O:20])[CH3:19])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6367Acetyl chloride2 回HCID 16457Benzeneethanol, alpha-methyl-, 1-acetateHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 204938272-Acetoxy-1-(4-acetylphenyl)propane

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

2-Acetoxy-1-phenylpropane (5.2 g) in acetyl chloride (20 ml) was added dropwise to a stirred solution of aluminium chloride (16.0 g) and acetyl chloride (4.2 ml) in dichloroethane (150 ml). The mixture was stirred at ambient temperature for 72 hours, poured on to ice (500 g) and the organic phase was separated. The organic phase and washings were washed with sodium bicarbonate solution, dried (MgSO4) and evaporated to an oil. Chromatography of the oil on alumina, eluting with ether/petrol gave the title compound (4.5 g).

後処理

  1. customthe organic phase was separated
  2. washThe organic phase and washings were washed with sodium bicarbonate solution
  3. dry with materialdried (MgSO4)
  4. customevaporated to an oil
  5. washChromatography of the oil on alumina, eluting with ether/petrol

出典と根拠

ORDレコード
ord-85d020a631a04043ac5817163c8fe86a
出典データセット
uspto-grants-1983_08
特許番号
US04396627

関連ノート

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