Phenyl isocyanate → N-(4-pyridazinyl)-N'-phenylurea

HRID 434457

反応式

HRID 434457 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

生成物 1

HCID 12893792N-(4-pyridazinyl)-N'-phenylurea

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

後処理

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

出典と根拠

ORDレコード
ord-9e4ffc2c86184b5a96e1e505db8d9a70
出典データセット
uspto-grants-1983_08
特許番号
US04397678

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