2-Hydroxyethyl acrylate → HCID 178460505、化合物
反応式
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:3]=1.O[CH2:16][CH2:17][O:18][C:19](=[O:22])[CH:20]=[CH2:21]>CN(C)C=O>[C:19]([O:18][CH2:17][CH2:16][O:13][C:12]([CH2:11][C:4]1[CH:3]=[C:2]([OH:1])[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=1)=[O:14])(=[O:22])[CH:20]=[CH2:21]参加物
4
実験手順
19.4 g of 7-hydroxy-5-carboxymethyl-1,2,4-triazolo[1,5-a]pyrimidine and 12 g of hydroxyethylacrylate were dissolved in 150 ml of dimethylformamide (DMF) and thereto, a solution of 20.6 g of N,N-dicyclohexylcarbodiimide in 30 ml of DMF was added dropwise at a room temperature for 10 minutes. Thereafter, stirring was continued at a room temperature for 8 hours, and the precipitate produced was removed by filtration. The filtrate was condensed under a reduced pressure and low temperature. The thus obtained residue was chromatographed through silica gel put in a column in order to separate it into components and purify. The intended compound was obtained in a form of crystal. It was recrystallized from ethyl acetate. Thus, 6 g of white crystal having a melting point of 108° to 109° C. (intended compound) was obtained.