Thiophosgene → 7-Isothiocyanatobenzofuran

HRID 434556ノート

反応式

HRID 434556 の反応式
[NH2:1][C:2]1[C:7]2[O:8][CH:9]=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:11](Cl)(Cl)=[S:12]>Cl>[N:1]([C:2]1[C:7]2[O:8][CH:9]=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1)=[C:11]=[S:12]

参加物

4

反応物 2

HCID 10040ThiophosgeneHCID 11217277Benzofuran-7-amine

生成物 1

HCID 130352777-Isothiocyanatobenzofuran

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7-Amino-benzo[b]furan is reacted with thiophosgene in 3 N hydrochloric acid at room temperature over 1 hour to give 7-isothiocyanatobenzo[b]furan. (M. Pt. 45°-46° from petroleum ether.) Reaction of this isothiocyanate with ethanolamine in ether gives N-benzo[b]furan-7-yl-N'-2-hydroxyethylthiourea (m.pt. 138°-139° from methanol) which is used further in the crude state.

出典と根拠

ORDレコード
ord-fc4e1b3e9de045519b57e73f78ffa978
出典データセット
uspto-grants-1983_08
特許番号
US04398028

反応ノート

読み込み中…