関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 4-Chloro-4-(chloromethyl)oxetan-2-one | HCID 13718281 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | Butanamide, 4-chloro-3-oxo-N-phenyl- | HCID 38215 | — |
反応手順
7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 150 parts of methylenechloride containing 4.2 parts of anhydrous sodium bicarbonate and the solution is cooled to 0° C. 4.7 Parts of aniline are then added over 30 minutes and the reaction mixture is finally stirred for 48 hours at room temperature. The solids are then filtered off and the filtrate evaporated. The residue is crystallised twice from chloroform to give γ-chloroacetoacetanilide, m.p. 142°-143° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04398033 |
|---|
| 出典データセット | uspto-grants-1983_08 |
|---|
| ORD ID | ord-1de118cf597a444a877d081882727599 |
|---|
| 出典メモ | uspto-grants-1983_08 |
|---|
