関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Thiophenemethanol | HCID 69467 | — |
| 反応物 | 1,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamine | HCID 78623 | — |
| 反応物 | 5-Fluoropyrimidin-2-one | HCID 101498 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Fluoro-1-(2-thienylmethyl)pyrimidin-2-one | HCID 20491766 | — |
反応手順
N,N-Dimethylformamide dineopentyl acetal (1.76 ml) was added to a stirred suspension of 5-fluoropyrimidin-2-one (456 mg) and 2-hydroxymethyl thiophene (0.7 ml) in dry N,N-dimethylformamide (8 ml) under nitrogen and the mixture was then heated at 80° C. After 1 h the reaction mixture was evaporated to a brown solid which was crystallised twice from ethyl acetate to give white crystals of the title pyrimidinone (230 mg), m.p. 161°-163° C., λmax (EtOH) 222.5 nm (ε 10,890), 333.5 nm (ε 3,660).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04399140 |
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| 出典データセット | uspto-grants-1983_08 |
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| ORD ID | ord-5bc85e7cc35d42269052212a80fa49d0 |
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| 出典メモ | uspto-grants-1983_08 |
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