2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoro-7-bromoindole

HRID 434677

反応式

HRID 434677 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1SC)=[C:8]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)[C:7]([F:19])=[CH:6][C:5]=2[Br:20]>[Ni].O1CCOCC1>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)[C:7]([F:19])=[CH:6][C:5]=2[Br:20]

参加物

4

反応物 1

HCID 202589822-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole

生成物 1

HCID 202589932-Methyl-4-morpholino-5-fluoro-7-bromoindole収率 65.3%

試薬・触媒・溶媒 2

HCID 935Nickel触媒2 回HCID 312751,4-Dioxane溶媒

実験手順

Raney nickel (400 g) was added to a solution of 58 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 1 l of dioxane and the mixture was allowed to react at room temperature for 4 hours. After completion of the reaction Raney nickel was removed by filtration, and the filtrate was concentrated under reduced pressure. 33 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole was obtained.

後処理

  1. customto react at room temperature for 4 hours
  2. customwas removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-bdc221d26d4a49d99d105f77bbed8a1c
出典データセット
uspto-grants-1983_08
特許番号
US04399134

関連ノート

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