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2-Methyl-2-butene → 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-2-butene | HCID 10553 | — |
| 反応物 | Sodium Chlorite | HCID 23668197 | — |
| 反応物 | Monosodium phosphate | HCID 23672064 | — |
| 反応物 | 5-Methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde | HCID 86648481 | — |
| 生成物 | 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid | HCID 67549808 | 118.2% |
反応手順
The same operation as in Example (33c) was performed using 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (36c) (90 mg, 0.51 mmol), sodium chlorite (95 mg, 1.05 mmol), sodium dihydrogenphosphate (154 mg, 0.99 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117 mg of the title compound as a white solid (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536197B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-3d5e398ed2a04ef081f57c6cbf8e141e |
| 出典メモ | uspto-grants-2013_09 |