化工社化工社 化学情報印刷レポート · 研究参考用
2-Methyl-2-butene → 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-2-butene | HCID 10553 | — |
| 反応物 | Sodium Chlorite | HCID 23668197 | — |
| 反応物 | Monosodium phosphate | HCID 23672064 | — |
| 反応物 | 5-Ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde | HCID 86648487 | — |
| 生成物 | 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid | HCID 67548558 | 99% |
反応手順
The same operation as in Example (33c) was performed using 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (39d) (110 mg, 0.57 mmol), sodium chlorite (108 mg, 1.19 mmol), sodium dihydrogenphosphate (178 mg, 1.14 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117.5 mg of the title compound as a white solid (99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536197B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-9cd2a23896944e8e8f3051454bacca09 |
| 出典メモ | uspto-grants-2013_09 |