2-Isopropylcyclohexan-1-ol → 2-Isopropylcyclohexan-1-one
反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1C1C=CC=C[NH+]=1.[Cr](Cl)([O-])(=O)=O.[CH:23]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]1[OH:32])([CH3:25])[CH3:24]>ClCCl>[CH:23]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][C:27]1=[O:32])([CH3:25])[CH3:24]参加物
4
実験手順
To a suspension of 4.0 g. (13.7 mmole) of 2,2'-bipyridinium chlorochromate in 15 ml of dichloromethane is added, while stirring, 0.5 g. (3.5 mmole) of 2-isopropylcyclohexanol in 10 ml of dichloromethane. The resulting reaction mixture is stirred for 4 hours and then filtered through a Hirsch funnel packed with 2 cm of Celite®. The resulting clear filtrate is washed with 5% hydrochloric acid and 10% sodium carbonate, and dried over magnesium sulfate. The drying agent is then removed and the solvent evaporated to yield a colorless oil which is distilled via Kugelrohr to yield pure 2-isopropylcyclohexanone in a typical yield of 0.425 g. which is 86% of theoretical yield.