Water → HCID 20492177、化合物

HRID 434779ノート

反応式

HRID 434779 の反応式
P(Cl)(Cl)(Cl)=O.[O:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH2:11][S:12][CH2:13][CH2:14][N:15]1[C:23](=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]1=[O:25].O.[CH:27]([OH:30])(C)C>CN(C)C=O>[CH:27]([C:10]1[O:6][C:7]([CH2:11][S:12][CH2:13][CH2:14][N:15]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:16]2=[O:25])=[CH:8][CH:9]=1)=[O:30]

参加物

6

反応物 4

HCID 962WaterHCID 3776IsopropanolHCID 24813Phosphorus oxychlorideHCID 132542762-(2-{[(Furan-2-yl)methyl]sulfanyl}ethyl)-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 20492177HCID 20492177、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of phosphoryl chloride (21.4 g) in dry dimethylformamide (40 ml), cooled in ice, was added portionwise to a solution of N-[2-[(2-furanylmethyl)thio]ethyl]-1H-isoindole-1,3(2H)-dione (21.4 g) in dry dimethylformamide (70 ml). After 5 hours at room temperature, the solution was poured into iced water (1.7 l). Isopropyl alcohol (150 ml) was added and after 18 hours the solid which separated was filtered and crystallised from ethyl acetate-ether to give the title compound (22.3 g) m.p. 76°-77°.

後処理

  1. customseparated
  2. filtrationwas filtered
  3. customcrystallised from ethyl acetate-ether

出典と根拠

ORDレコード
ord-1eacc8d32d3c4d44976bc24771abbedd
出典データセット
uspto-grants-1983_08
特許番号
US04399294

反応ノート

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