関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 3-Aminobenzoic Acid | HCID 7419 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-(Dimethylamino)benzoic acid | HCID 66837 | — |
| 反応物 | Crystal Violet lactone | HCID 73773 | — |
| 反応物 | 4,4'-Bis(dimethylamino)benzhydrol | HCID 92742 | — |
| 生成物 | 2-(Bis(4-(dimethylamino)phenyl)methyl)-5-(dimethylamino)benzoic acid | HCID 102063 | — |
反応手順
U.S. Pat. No. 2,417,897 and its corresponding U.S. Reissue Pat. No. 23,024, which issued Mar. 25, 1947 and Aug. 17, 1948, respectively, disclose a three-step process for the preparation of 3,3-bis(4-dimethylaminophenyl)-6-dimethylaminophthalide, Crystal Violet Lactone (CVL). In the first step, 3-dimethylaminobenzoic acid is prepared from 3-aminobenzoic acid by alkylating the free amine using methyl iodide in the presence of potassium hydroxide. In the second step, the 3-dimethylaminobenzoic acid is condensed with 4,4'-bis(dimethylamino)benzhydrol in the presence of sulfuric acid to obtain 2-[bis(4-dimethylaminophenyl)methyl]-5-dimethylaminobenzoic acid. In the third step, the 2-[bis(4-dimethylaminophenyl)methyl]-5-dimethylaminobenzoic acid is oxidized using lead dioxide in dilute hydrochloric acid to obtain the CVL.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04399291 |
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| 出典データセット | uspto-grants-1983_08 |
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| ORD ID | ord-150cf44b08cb4d59ad21ea436c27bb20 |
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| 出典メモ | uspto-grants-1983_08 |
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