Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-propoxyiminoacetic acid
反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH2:14][CH3:15])[C:8]([OH:10])=[O:9])[N:6]=1.[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH2:14][CH3:15])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:18]参加物
4
実験手順
2-(2-Aminothiazol-4-yl)-2-n-propoxyiminoacetic acid (syn isomer, 21.8 g.), acetic anhydride (38.8 g.) and formic acid (17.5 g.) were treated in a similar manner to that of Example F-(5), and then the obtained oil was triturated with diisopropyl ether to give 2-(2-formamidothiazol-4-yl)-2-n-propoxyiminoacetic acid (syn isomer, 19.2 g.), mp. 164° C. (dec.).
後処理
- customthe obtained oil was triturated with diisopropyl ether
出典と根拠
- ORDレコード
- ord-5b0c8b44477449698f33769daf143d10
- 出典データセット
- uspto-grants-1983_08
- 特許番号
- US04399133
反応ノート
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