Triethylamine → HCID 22662877、化合物

HRID 43501ノート

反応式

HRID 43501 の反応式
[OH:1][CH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH3:8].C(N(CC)CC)C.[Si:16](Cl)([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17].C(OCC)(=O)C>CN(C=O)C>[Si:16]([O:1][CH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH3:8])([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 28928tert-Butyldimethylsilyl chlorideHCID 1224334-hydroxymethyl-5-methyl-1H-imidazole

生成物 1

HCID 22662877HCID 22662877、化合物収率 77%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-(Hydroxymethyl)-5-methyl-1H-imidazole (4 g, 26.9 mmol) was dissolved in DMF (80 mL). Triethylamine (13.5 mL, 96.9 mmol) and tert-butyl(dimethyl)silyl chloride (4.68 g, 31.0 mmol) were added, followed by stirring for three hours. Ethyl acetate was added to the reaction solution, and the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, dichloromethane/methanol=92/8) to obtain 4.67 g of the title compound (77%).

後処理

  1. washthe organic layer was washed with brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentration under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, dichloromethane/methanol=92/8)

出典と根拠

ORDレコード
ord-4b12e4695cd24b6ab86a97e8736a2e67
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

反応ノート

読み込み中…