Hydrochloric Acid → (E)-1-(4-hydroxyphenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride

関与物質

反応手順

4.86 g (0.03 mole) of 4-(4-hydroxyphenyl)-3-buten-2-one, 1.2 g (0.04 mole) of paraformaldehyde and 2.6 g (0.03 mole) of morpholine is added to 60 ml of ethanol and 6 ml of concentrated HCl is added thereto. The mixture is heated at reflux temperature for 18 hours and then cooled to room temperature. The resultant mixture is diluted with acetone to a volume of 250 ml and subsequently chilled overnight. The insoluble material is filtered and recrystallized from a mixture of ethyl and methyl alcohols. The crystals are filtered and vacuum dried overnight, yielding (E)-1-(4-hydroxyphenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride; m.p. 195°-196° C.

情報源と証拠