Ethanol → Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate
反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH:7]([C:9]([OH:11])=[O:10])[O:8][C:4]=2[C:3]=1[Cl:14].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[CH2:20]([O:10][C:9]([CH:7]1[CH2:6][C:5]2[CH:12]=[CH:13][C:2]([Cl:1])=[C:3]([Cl:14])[C:4]=2[O:8]1)=[O:11])[CH3:21]参加物
4
実験手順
A solution of 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid (70 g.) conc. sulfuric acid (2 ml.) and ethanol (250 ml.) is refluxed for 2 hours. The ethanol is distilled at reduced pressure and the residue is suspended in saturated sodium bicarbonate and extracted with ether. The ether solution is washed with brine, dried over magnesium sulfate and the ether distilled at reduced pressure. The 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester is used without further purification in the following synthesis.
後処理
- distillationThe ethanol is distilled at reduced pressure
- extractionextracted with ether
- washThe ether solution is washed with brine
- dry with materialdried over magnesium sulfate
- distillationthe ether distilled at reduced pressure
- customThe 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester is used without further purification in the following synthesis
出典と根拠
- ORDレコード
- ord-b183a7e0b96b40f69cfc3f16c2fe13d1
- 出典データセット
- uspto-grants-1983_08
- 特許番号
- US04401669
反応ノート
読み込み中…