関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Benzophenone | HCID 3102 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | N-(4-benzoylphenyl)acetamide | HCID 228532 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-Acetamido-3-nitrobenzophenone | HCID 596969 | 62.5% |
反応手順
Twenty-three grams (0.1 mole) of 4-acetamidobenzophenone, 50 ml. of acetic anhydride and 20 ml. of acetic acid were stirred together. A solution of 90 percent nitric acid (15 ml.), 10 ml. of acetic acid and 0.2 g. of urea was added dropwise to the benzophenone mixture. The reaction mixture was maintained at a temperature of about 50° C. during the nitration. The mixture was stirred at ambient temperature whereupon the mixture became very thick. The thick slurry was poured over ice and the insoluble product was filtered to yield 17.7 g. (62.5 percent yield) of 4-acetamido-3-nitrobenzophenone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04401817 |
|---|
| 出典データセット | uspto-grants-1983_08 |
|---|
| ORD ID | ord-5c1741aa26614ec59dfff7e5e3ef1907 |
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| 出典メモ | uspto-grants-1983_08 |
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