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Phenol → alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Chlorobenzenepropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | N-(1-methylethyl)-3-(3-chlorophenyl)-2-oxiranecarboxamide | HCID 13041335 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Chlorobenzenepropanamide | HCID 13041346 | — |
反応手順
This compound was prepared from N-(1-methylethyl)-3-(3-chlorophenyl)-2-oxiranecarboxamide (7.2 g.), phenol (3.0 g.), sodium hydride (50% oil dispersion, 1.6 g.), 18-crown-6 (0.9 g.) and acetonitrile (250 ml.) as described in Example 12. The crude product was recrystallized from ether. The compound melted at 160°-162°, and weighed 1.7 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04401832 |
| 出典データセット | uspto-grants-1983_08 |
| ORD ID | ord-36de2296413e41dfb4560091010942ff |
| 出典メモ | uspto-grants-1983_08 |