化工社化工社 化学情報印刷レポート · 研究参考用
Phenol → alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-4-Chlorobenzenepropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | N-(1-methylethyl)-3-(4-chlorophenyl)-2-oxiranecarboxamide | HCID 13041336 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-4-Chlorobenzenepropanamide | HCID 13041347 | — |
反応手順
This compound was prepared from N-(1-methylethyl)-3-(4-chlorophenyl)-2-oxiranecarboxamide (7.2 g.), phenol (3.0 g.), sodium hydride (50% oil dispersion, 1.6 g.), 18-crown-6 (0.9 g.), and acetonitrile (250 ml.) as described in Example 12. The crude product was recrystallized from ethanol, giving 2.3 g. of the compound, m.p. 175°-177°. Another recrystallization from ethanol gave analytical sample, m.p. 176°-178°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04401832 |
| 出典データセット | uspto-grants-1983_08 |
| ORD ID | ord-0dc2efa9a2184257883d10c011c4190b |
| 出典メモ | uspto-grants-1983_08 |