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4-Chlorophenol → alpha-Hydroxy-beta-(4-Chlorophenoxy)-N-(1-Methylethyl)-4-Chlorobenzenepropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenol | HCID 4684 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | N-(1-methylethyl)-3-(4-chlorophenyl)-2-oxiranecarboxamide | HCID 13041336 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | alpha-Hydroxy-beta-(4-Chlorophenoxy)-N-(1-Methylethyl)-4-Chlorobenzenepropanamide | HCID 13041348 | — |
反応手順
This compound was prepared from N-(1-methylethyl)-3-(4-chlorophenyl)-2-oxiranecarboxamide (9.56 g.), p-chlorophenol (5.2 g.), sodium hydride (50% oil dispersion, 2.0 g.) 18-crown-6 (3.0 g.), and acetonitrile (300 ml.) as described in Example 12, and purified by recrystallization from ether. The compound melted at 177°-179°, and weighed 0.76 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04401832 |
| 出典データセット | uspto-grants-1983_08 |
| ORD ID | ord-8ff4bd9544a14d28bffc2941761c3c75 |
| 出典メモ | uspto-grants-1983_08 |