Methyl bromoacetate → 3-Bromo-2-methoxyphenoxyacetic acid methyl ester

HRID 435507ノート

反応式

HRID 435507 の反応式
[Br:1][C:2]1[C:3]([O:9][CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:12][C:13]([O:15][CH3:16])=[O:14]>>[CH3:16][O:15][C:13](=[O:14])[CH2:12][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[C:3]=1[O:9][CH3:10]

参加物

3

反応物 2

HCID 60984Methyl bromoacetateHCID 218775343-Bromo-2-methoxyphenol

生成物 1

HCID 541832043-Bromo-2-methoxyphenoxyacetic acid methyl ester

実験手順

The compound of Formula XVIII wherein s is zero can also be prepared by treating 3-bromo-2-methoxyphenol with methyl bromoacetate to give 3-bromo-2-methoxyphenoxyacetic acid methyl ester which is reduced to the alcohol using, e.g., diisobutylaluminum hydride with subsequent protection of the alcohol with an R12 protecting group as generally described hereinbefore.

後処理

  1. customcan also be prepared

出典と根拠

ORDレコード
ord-992ba6eabc2d43408cdc5486d3186ed8
出典データセット
uspto-grants-1983_08
特許番号
US04401824

反応ノート

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