Methanol → Methyl 3-bromo-6-(phenylthio)-benzoate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:18]O>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:9][CH:10]=1)[C:5]([O:7][CH3:18])=[O:6]参加物
4
実験手順
478 g of 3-bromo-6-(phenylthio)-benzoic acid in 1.5 litres of methanol and 200 ml of concentrated sulphuric acid are heated under reflux for 8 hours. The solution is concentrated under reduced pressure, treated with water and extracted with water. The organic solution is washed with aqueous sodium bicarbonate solution, dried over magnesium sulphate and concentrated under reduced pressure. There is obtained methyl 3-bromo-6-(phenylthio)-benzoate as a yellow oil.
後処理
- temperatureunder reflux for 8 hours
- concentrationThe solution is concentrated under reduced pressure
- additiontreated with water
- extractionextracted with water
- washThe organic solution is washed with aqueous sodium bicarbonate solution
- dry with materialdried over magnesium sulphate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-ca0f3d8f232543b5b12f4da66edcf61d
- 出典データセット
- uspto-grants-1977_02
- 特許番号
- US04006145
反応ノート
読み込み中…