Hydrochloric Acid → 10-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

HRID 435649ノート

反応式

HRID 435649 の反応式
[ClH:1].[CH3:2][N:3]([CH3:23])[S:4]([C:7]1[CH:22]=[CH:21][C:10]2[S:11][C:12]3[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=3[CH:14](O)[CH2:15][C:9]=2[CH:8]=1)(=[O:6])=[O:5].[Cl-].[Ca+2].[Cl-]>C1C=CC=CC=1>[Cl:1][CH:14]1[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[S:11][C:10]2[CH:21]=[CH:22][C:7]([S:4](=[O:6])(=[O:5])[N:3]([CH3:23])[CH3:2])=[CH:8][C:9]=2[CH2:15]1

参加物

5

反応物 3

HCID 313Hydrochloric Acid2 回HCID 5284359Calcium ChlorideHCID 12223972HCID 12223972、化合物

生成物 1

HCID 1561900510-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Hydrochloric acid gas is introduced at 10° C for 2 hours into a mixture of 12 g of 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin-10-ol, 250 ml of benzene and 20 g of calcium chloride. The mixture is then left to stand at room temperature for 20 hours. The excess hydrochloric acid is driven off by the introduction of nitrogen. The mixture is filtered and evaporated under reduced pressure. 10-chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin is obtained.

後処理

  1. waitThe mixture is then left
  2. filtrationThe mixture is filtered
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-cca5d19679774d61aaa2a9be6f55b303
出典データセット
uspto-grants-1977_02
特許番号
US04006145

反応ノート

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