Potassium Cyanide → 3-Methyl-6-(phenylthio)-phenylacetonitrile

HRID 435666ノート

反応式

HRID 435666 の反応式
[C-:1]#[N:2].[K+].[CH3:4][C:5]1[CH:6]=[C:7]([C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)[CH2:8]Cl>O.C(O)C>[CH3:4][C:5]1[CH:6]=[C:7]([CH2:8][C:1]#[N:2])[C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 125391003-Methyl-6-(phenylthio)-benzyl chloride

生成物 1

HCID 125391013-Methyl-6-(phenylthio)-phenylacetonitrile

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

194 g of potassium cyanide in 250 ml of water are heated under reflux for 17 hours under an argon atmosphere with 616.9 g of 3-methyl-6-(phenylthio)-benzyl chloride in 900 ml of ethanol. Then the ethanol is distilled off under reduced pressure, the residue then diluted with water and extracted with ether. The extracts are washed with water, dried over sodium sulphate and evaporated. There is obtained 3-methyl-6-(phenylthio)-phenylacetonitrile as an oil.

後処理

  1. distillationThen the ethanol is distilled off under reduced pressure
  2. additionthe residue then diluted with water
  3. extractionextracted with ether
  4. washThe extracts are washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated

出典と根拠

ORDレコード
ord-0e7610fd672145cb80db885400d10957
出典データセット
uspto-grants-1977_02
特許番号
US04006144

反応ノート

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