2-(Cyclohexylthio)-1H-isoindole-1,3(2H)-dione → Phthalimide

HRID 435729

反応式

HRID 435729 の反応式
C1(S[N:8]2[C:12](=[O:13])[C:11]3=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]3[C:9]2=[O:18])CCCCC1>CCCCCCC>[C:12]1(=[O:13])[NH:8][C:9](=[O:18])[C:10]2=[CH:17][CH:16]=[CH:15][CH:14]=[C:11]12

参加物

3

反応物 1

HCID 287772-(Cyclohexylthio)-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 6809Phthalimide

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

13.1 Grams (0.05 mole) of N-(cyclohexylthio)phthalimide and 6.9 grams (0.05 mole) of benzoyl thiol(thiobenzoic acid) in 150 ml of heptane are stirred overnight at room temperature. The precipitate is recovered by filtration, washed with carbon tetrachloride and dried. 7.3 Grams of phthalimide (m.p. 234° C) are obtained. The solvent is removed from the filtrate by evaporation under reduced pressure. 12 Grams (95% yield) of product, a light brown liquid, are obtained. The identity of the benzoylcyclohexyl disulfide is confirmed by GLC and NMR analyses. Analysis gives 25.51% sulfur compared to 25.45% sulfur calculated for C13H16OS2. Similarly, except N-(2-benzothiazolylthio)phthalimide is one reactant, there is obtained benzoyl-2-benzothiazolyl disulfide.

後処理

  1. filtrationThe precipitate is recovered by filtration
  2. washwashed with carbon tetrachloride
  3. customdried

出典と根拠

ORDレコード
ord-1f3f968f02cf4a27bffac25feb1237a1
出典データセット
uspto-grants-1977_02
特許番号
US04006155

関連ノート

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