Acetic Acid → 4-Carboxybutylcyclopentan-1-one
反応式
[C:1]([CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[CH2:14][CH2:13][CH2:12][C:11]1=[O:15])([O:3]CC)=[O:2].Cl.C(O)(=O)C>O>[C:1]([CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[CH2:14][CH2:13][CH2:12][C:11]1=[O:15])([OH:3])=[O:2]参加物
5
実験手順
A stirred mixture of 274 g. of 2-carbalkoxy(mixed methyl and ethyl esters)-2-(4-carbethoxybutyl)cyclopentan-1-one (Example 1), 600 ml. of 20% hydrochloric acid and 325 ml. of acetic acid is heated at reflux for 20 hours. Solution occurs in approximately 1/2 hour. The solution is cooled and diluted with water and extracted with ether. The combined extracts are washed with saline and dried over magnesium sulfate and evaporated. The residue is evaporated twice with toluene to give 144 g. of an oil.
後処理
- additionA stirred mixture of 274 g
- temperatureat reflux for 20 hours
- temperatureThe solution is cooled
- extractionextracted with ether
- washThe combined extracts are washed with saline
- dry with materialdried over magnesium sulfate
- customevaporated
- customThe residue is evaporated twice with toluene
- customto give 144 g
出典と根拠
- ORDレコード
- ord-6bd3ee2225b14b8e9fbefd0780936d67
- 出典データセット
- uspto-grants-1977_02
- 特許番号
- US04006179
反応ノート
読み込み中…