Acetic Anhydride → 1-Acetoxy-2-(carbethoxymethyl)cyclopent-1-ene

反応式

[C:1]([CH2:6][CH:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])([O:3][CH2:4][CH3:5])=[O:2].[C:13](OC(=O)C)(=[O:15])[CH3:14].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[C:13]([O:12][C:8]1[CH2:9][CH2:10][CH2:11][C:7]=1[CH2:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])(=[O:15])[CH3:14]

参加物

反応物 3

HCID 7918Acetic Anhydride

HCID 521998p-Toluenesulfonic acid monohydrate

HCID 2723663Ethyl 2-(2-oxocyclopentyl)acetate

生成物 1

HCID 203242041-Acetoxy-2-(carbethoxymethyl)cyclopent-1-ene

実験手順

In the manner described in Example 10, treatment of 2-(carbethoxymethyl)cyclopentan-1-one (Example 210) with acetic anhydride and p-toluenesulfonic acid monohydrate gives an oil, b.p. 130°-131° C. (7 mm).