2,3,5-Trimethylanisole → (4-Methoxy-2,3,6-trimethylphenyl)(5-nitro-1,3-thiazol-2-yl)methanone

HRID 435812

反応式

HRID 435812 の反応式
[N+:1]([C:4]1[S:8][C:7]([C:9](Cl)=[O:10])=[N:6][CH:5]=1)([O-:3])=[O:2].[CH3:12][C:13]1[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=1[O:21][CH3:22].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:22][O:21][C:14]1[CH:15]=[C:16]([CH3:20])[C:17]([C:9]([C:7]2[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][N:6]=2)=[O:10])=[C:18]([CH3:19])[C:13]=1[CH3:12]

参加物

5

反応物 3

HCID 885552,3,5-TrimethylanisoleHCID 6451240Aluminum(III) ChlorideHCID 148422765-Nitrothiazole-2-carbonyl chloride

生成物 1

HCID 21481569(4-Methoxy-2,3,6-trimethylphenyl)(5-nitro-1,3-thiazol-2-yl)methanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

One gram of 5-nitrothiazole-2-carboxylic acid chloride in 10 ml. of methylene chloride is combined with 850 mg. of 2,3,5-trimethylanisole and then with 1.6 g. of aluminum chloride. After three hours of agitation at room temperature, the reaction mixture is poured on 50 ml. of 1N HCl and extracted with ethyl acetate. After drying of the solution and evaporating the solvent under vacuum, the crystalline residue is recrystallized from methanol/chloroform.

後処理

  1. additionthe reaction mixture is poured on 50 ml
  2. extractionof 1N HCl and extracted with ethyl acetate
  3. customAfter drying of the solution
  4. customevaporating the solvent under vacuum
  5. customthe crystalline residue is recrystallized from methanol/chloroform

出典と根拠

ORDレコード
ord-2d72e8aae1df4bf88be3a81bd9d3f0bc
出典データセット
uspto-grants-1977_02
特許番号
US04006241

関連ノート

読み込み中…