Ethanol → 1,2-Epoxy-3-(2-propylphenoxy)propane

HRID 435859

反応式

HRID 435859 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])[CH2:2][CH3:3].Cl[CH2:12][CH:13]1[O:15][CH2:14]1.C(O)C.[OH-].[K+]>O>[O:15]1[CH:13]([CH2:12][O:10][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:1][CH2:2][CH3:3])[CH2:14]1

参加物

6

反応物 4

HCID 702Ethanol2 回HCID 7835EpichlorohydrinHCID 125702-PropylphenolHCID 14797Potassium Hydroxide

生成物 1

HCID 123558511,2-Epoxy-3-(2-propylphenoxy)propane

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a solution of 27.2 parts of 2-propylphenol and 56 parts of 1-chloro-2,3-epoxypropane in 30 parts of ethyl alcohol, heated under reflux, was added a solution of 13.2 parts of potassium hydroxide in 50 parts of ethyl alcohol and 6 parts of water over 15 minutes and the mixture obtained was heated under reflux for a further 2 hours. The mixture was poured into 1,000 parts of water and extracted with ethyl acetate. The organic phase was separated, washed with water, dried over magnesium sulphate, filtered and evaporated to yield a yellow oil. The oil was distilled at the water pump to yield 31.0 parts of 1,2-epoxy-3-(2-propylphenoxy)propane, boiling point 155°-158° at 15 mm.

後処理

  1. temperatureunder reflux
  2. customthe mixture obtained
  3. temperaturewas heated
  4. temperatureunder reflux for a further 2 hours
  5. extractionextracted with ethyl acetate
  6. customThe organic phase was separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulphate
  9. filtrationfiltered
  10. customevaporated
  11. customto yield a yellow oil
  12. distillationThe oil was distilled at the water pump

出典と根拠

ORDレコード
ord-bdba7b5fbdc1401bb7ed2f4102362e0e
出典データセット
uspto-grants-1977_02
特許番号
US04006245

関連ノート

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