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Formic Acid → N-(3-(dimethylamino)propyl)formamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(3-(dimethylamino)propyl)formamide | HCID 80020 | 59% |
反応手順
Formic acid (23 g., 0.5 mole), dimethylaminopropylamine (51 g., 0.5 mole) and toluene (50 ml) were azeotroped together with continual removal of water using a Dean and Stark separator until no more water was formed. Toluene was distilled off and the pale yellow residue distilled in vacuo. The colourless liquid product of low smell (N-(3-dimethylaminopropyl)formamide) was obtained in a yield of 59% of theory, b.p. 140° C/15 mm Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04007140 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-e537d7b8b53e40359f2afc800bf1e2f2 |
| 出典メモ | uspto-grants-1977_02 |