2-Fluorophenyl isocyanate → HCID 54351266、化合物
反応式
[CH3:1][NH:2][C:3]([NH:5][O:6][CH3:7])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]=[C:16]=[O:17]>C1(C)C(C)=CC=CC=1>[CH3:1][NH:2][C:3]([N:5]([O:6][CH3:7])[C:16]([NH:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[F:8])=[O:17])=[O:4]参加物
4
実験手順
To 35 g (0.27 mol) of 1-methyl-3-methoxy urea in 150 ml xylene was added dropwise a solution of 37 g (0.27 mol) 2-fluorophenylisocyanate in 100 ml of xylene. The reaction mixture was refluxed for 4 hours. The reaction mixture was filtered while warm to remove a small amount of triethylamine hydrochloride (impurity in the urea reactant). The filtrate was evaporated to give the biuret product as a solid (m.p. 144°-147° C after recrystallization from benzene). Elemental analysis for fluorine showed: calc. 7.88%, found 7.64%.
後処理
- temperatureThe reaction mixture was refluxed for 4 hours
- filtrationThe reaction mixture was filtered
- temperaturewhile warm
- customto remove a small amount of triethylamine hydrochloride (impurity in the urea reactant)
- customThe filtrate was evaporated
- customto give
- customthe biuret product as a solid (m.p. 144°-147° C after recrystallization from benzene)
出典と根拠
- ORDレコード
- ord-bf8f8915431d45f58f1697da2a3240a1
- 出典データセット
- uspto-grants-1977_02
- 特許番号
- US04007175
反応ノート
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