Sulfuric Acid → 2-(2-Isopropyl-1-oxoindan-6-yl)propionic acid

HRID 435971

反応式

HRID 435971 の反応式
S(=O)(=O)(O)O.[C:6]([CH:9]([CH:22]([CH3:24])[CH3:23])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1)([OH:8])=O>>[CH:22]([CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=2)[C:6]1=[O:8])([CH3:24])[CH3:23]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 214548962-[4-(2-Carboxy-3-methylbutyl)phenyl]propionic acid

生成物 1

HCID 126278922-(2-Isopropyl-1-oxoindan-6-yl)propionic acid

実験手順

To 120 ml. of conc. sulfuric acid was added 26g. of 2-[4-(2-carboxy-3-methylbutyl)phenyl]propionic acid and the mixture was heated at 100° C. for 3 hours. The mixture was poured into ice-water and extracted with ether. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness. The residue was subjected to vacuum distillation to give 15.7g. of the desired product boiling at 184° C./0.002 mmHg. as a colorless oil.

後処理

  1. extractionextracted with ether
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated to dryness
  5. distillationThe residue was subjected to vacuum distillation
  6. customto give 15.7g

出典と根拠

ORDレコード
ord-b3b28c2dab0d43f080711e5eaf2f5b5f
出典データセット
uspto-grants-1977_02
特許番号
US04007179

関連ノート

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