Hydrochloric Acid → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 435972

反応式

HRID 435972 の反応式
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])=[CH:9][CH:10]=2)[C:5]1=O)([CH3:3])[CH3:2].Cl.O1CCOCC1>O>[CH:1]([CH:4]1[CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=2)[CH2:12]1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 126278922-(2-Isopropyl-1-oxoindan-6-yl)propionic acid

生成物 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 15g. of 2-(2-isopropyl-1 -oxoindan-6-yl)propionic acid, 40g. of zinc amalgam, 50 ml. of conc. hydrochloride acid, 200 ml. of dioxane and 30 ml. of water was heated under reflux for 15 hours. After completion of the reaction, the reaction mixture was extracted with ether and the ether extract was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off from the extract and the residue was recrystallized from n-hexane to give 9.5g. of the desired product as colorless crystals of m.p. 90° - 91.5° C.

後処理

  1. temperatureunder reflux for 15 hours
  2. customAfter completion of the reaction
  3. extractionthe reaction mixture was extracted with ether
  4. extractionthe ether extract
  5. washwas washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationThe solvent was distilled off from the
  8. extractionextract
  9. customthe residue was recrystallized from n-hexane
  10. customto give 9.5g

出典と根拠

ORDレコード
ord-679964d845704a9f8f13557841ed8dc5
出典データセット
uspto-grants-1977_02
特許番号
US04007179

関連ノート

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