化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-(Hydroxymethyl)-7-methoxy-9H-xanthen-9-OL
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | Ethyl 7-methoxy-9-oxoxanthene-2-carboxylate | HCID 21455094 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Hydroxymethyl)-7-methoxy-9H-xanthen-9-OL | HCID 21455095 | 84% |
反応手順
Lithium aluminum hydride (500 mg) was added to a stirred solution of ethyl 7-methoxy-9-oxoxanthene-2-carboxylate (1g) in THF (100 ml). The reaction mixture was stirred at room temperature under nitrogen for 5 hours. Water and MgSO4 were added. The inorganic solids were filtered off and washed with ethyl acetate. The filtrate and washings were combined and evaporated to give the crude product. Recrystallization from ethyl acetate gave white crystals (0.82 g, 84%), mp. 142°-143°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04007205 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-67a38b1b31974630bd45356f0540d6db |
| 出典メモ | uspto-grants-1977_02 |