関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Nitrophenyl trifluoroacetate | HCID 69569 | — |
| 反応物 | 1,2,3,4-Tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid | HCID 90301 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | HCID 178524481 | HCID 178524481 | 65.3% |
反応手順
Uracil-5-carboxylic acid (1.0 g) is dissolved in dry pyridine (20 ml) under heating. p-Nitrophenyl trifluroacetate (1.8 g) is added to the solution which is subsequently stirred at 45° C for 30 minutes. Then, the solution is concentrated to dryness under reduced pressure, and the cyrstals thus obtained are washed with chloroform and then acetone to give the active ester, i.e. p-nitrophenyl 2,4-dihydroxypyrimidine-5-carboxylate (1.16 g). M.P. 298°-299° C (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04008220 |
|---|
| 出典データセット | uspto-grants-1977_02 |
|---|
| ORD ID | ord-973d09fdd4f848038325b3f993b5ec89 |
|---|
| 出典メモ | uspto-grants-1977_02 |
|---|
