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2-Methylcinnamic aldehyde → 1-[2-(2-Methyl-3-phenylallylidene)hydrazino]-6,7-dimethoxy-3,4-dihydroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylcinnamic aldehyde | HCID 7557 | — |
| 反応物 | Ethanol, mixt. with methanol | HCID 18681192 | — |
| 反応物 | 1-Hydrazino-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride | HCID 68122437 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 1-[2-(2-Methyl-3-phenylallylidene)hydrazino]-6,7-dimethoxy-3,4-dihydroisoquinoline | HCID 57311439 | — |
反応手順
In a manner similar to that of Example 18 condensation of 1-hydrazino-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride (9 g.) and α-methylcinnamaldehyde (5.62 g.) and recrystallization of the resulting product first from ethanol-methanol and then from ethanol-water afforded 1-[2-(2-methyl-3-phenylallylidene)hydrazino]-6,7-dimethoxy-3,4-dihydroisoquinoline (I: X= C6H5CH=C(CH3), X' = Y = Y' = H, Z = Z' = CH3O) hydrochloride monohydrate (10.2 g., m.p. 215°-217° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009170 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-896d0be707374c48b9f093b7f4b65ce5 |
| 出典メモ | uspto-grants-1977_02 |