Acetic Acid → 6-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide

HRID 436460

反応式

HRID 436460 の反応式
C(O)(=[O:3])C.[O:5]([CH2:12][C:13]([NH:15][CH:16]1[C:27](=[O:28])[N:18]2[CH:19]([C:24]([OH:26])=[O:25])[C:20]([CH3:23])([CH3:22])[S:21][C@H:17]12)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.OO>O.O.[O-][W]([O-])(=O)=O.[Na+].[Na+].O>[O:5]([CH2:12][C:13]([NH:15][CH:16]1[C:27](=[O:28])[N:18]2[CH:19]([C:24]([OH:26])=[O:25])[C:20]([CH3:23])([CH3:22])[S:21](=[O:3])[C@H:17]12)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 123738936-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid

生成物 1

HCID 122939416-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide

試薬・触媒・溶媒 2

HCID 150191Sodium Tungstate Dihydrate触媒HCID 962Water溶媒

実験手順

Acetic acid (10 cc) was added to 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid (3.50 g.), and sodium tungstate dihydrate (100 mg.) was further added thereto. To the mixture was added 30% hydrogen peroxide (1.2 cc) while cooling in an ice bath, and the mixture was stirred for 1 hour. Water was added to the mixture and the precipitate was collected by filtration, washed with water and dried to yield crystals (3.24 g.) of 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide, m.p. 166°-167° C.

後処理

  1. additionwas further added
  2. temperaturewhile cooling in an ice bath
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-ed2032780e4f4036bb49b63a1b08404e
出典データセット
uspto-grants-1977_02
特許番号
US04009159

関連ノート

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