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Sulfuric Acid → 4-Amino-3-methyl-N-ethyl-N-(beta-(methanesulfonamido)ethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | N-(2-Chloroethyl)methanesulphonamide | HCID 89092 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-(N-p-Toluenesulfonyl)amino-3-methyl-N-ethylaniline | HCID 21452835 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-Amino-3-methyl-N-ethyl-N-(beta-(methanesulfonamido)ethyl)aniline | HCID 66693 | — |
反応手順
A mixture of 7g of 4-(N-p-toluenesulfonyl)amino-3-methyl-N-ethylaniline, 4g of β-methanesulfonamidoethyl chloride, 2.1g of sodium hydrogen carbonate, 16g of water and 30ml of methanol were refluxed for 5 hours, and then 16g of sulfuric acid were added thereto and the entire reaction system was again refluxed. Next, the reaction solution was condensed to half the original volume and 300ml of isopropyl alcohol were added thereto to separate crystals. The crystals were filtered out and dried to obtain 1.5g of 4-amino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline. sesquisulfate. H2O.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009205 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-3e871e83a4f9492bbd2264290214c3df |
| 出典メモ | uspto-grants-1977_02 |