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Diethyl Sulfate → N-[4-(diethylamino)-2-methylphenyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Sulfate | HCID 6163 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Acetamino-3-methyl-N-ethylaniline | HCID 21452831 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[4-(diethylamino)-2-methylphenyl]acetamide | HCID 222177 | 64.4% |
反応手順
19.1g (0.1 mole) of 4-acetamino-3-methyl-N-ethylaniline obtained in Example 1, Part C, and 100g of water were mixed, and, after 12.5g of diethyl sulfate were added dropwise thereto while stirring, the entire reaction system was stirred overnight at room temperature. Next, the reaction mixture was neutralized with sodium hydroxide and the crystals separated were recrystallized from methanol to obtain 11.5g of white crystals of 4-acetamino-3-methyl-(N,N-diethyl)aniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009205 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-07f5cee7c9e849128dbff41ea39d7b24 |
| 出典メモ | uspto-grants-1977_02 |