Methanol → 4-(Benzyloxy)-3,5-diphenyl-1H-pyrazole

HRID 436609ノート

反応式

HRID 436609 の反応式
[C:1]1([C:7]2[C:11]([OH:12])=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].CO.[CH2:24](Cl)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O>[CH2:24]([O:12][C:11]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8][NH:9][C:10]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

6

反応物 4

HCID 887MethanolHCID 7503Benzyl ChlorideHCID 3149543,5-diphenyl-1H-pyrazol-4-olHCID 10942334Sodium Methoxide

生成物 1

HCID 213980924-(Benzyloxy)-3,5-diphenyl-1H-pyrazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A mixture of 3,5-diphenyl-4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60° C for 2 hours. Then benzyl chloride is added slowly at 60° C. A white solid forms. Heating is continued overnight at 60° C. The reaction mixture is examined by glc and the reaction is found to be complete. The mixture is poured into water and the solid isolated by filtration. The solid is washed well with water, dried and recrystallized from acetonitrile to give pale yellow crystals, melting point 152°-152.5° C.

後処理

  1. temperatureHeating
  2. customthe solid isolated by filtration
  3. washThe solid is washed well with water
  4. customdried
  5. customrecrystallized from acetonitrile
  6. customto give pale yellow crystals, melting point 152°-152.5° C.

出典と根拠

ORDレコード
ord-26a46b394f8c4bcb9d094c10cb4dc312
出典データセット
uspto-grants-1977_02
特許番号
US04009277

反応ノート

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