Acetic Anhydride → N-(3,5-Dichlorophenyl)glutarimide

HRID 436612ノート

反応式

HRID 436612 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(OC(=O)C)(=O)C.C([O-])(=O)C.[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:10](=[O:17])[CH2:11][CH2:12][CH2:13][C:14]2=[O:16])[CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 2732356HCID 2732356、化合物

生成物 1

HCID 169473N-(3,5-Dichlorophenyl)glutarimide

実験手順

A mixture comprising 27.6 g. of N-(3,5-dichlorophenyl) glutaric acid monoamide, 50 g. of acetic anhydride and 1 g. of anhydrous sodium acetate was fed to a 100 ml. four-necked flask and was heated with stirring at 80° - 90° C. for 1 hour. Thereafter, the acetic acid and acetic anhydride were removed by distillation under reduced pressure, and the residue was washed with water and then dried to obtain 24.8 g. of the above-mentioned compound in the form of white crystals, m.p. 172.5° - 174.5° C.

後処理

  1. temperaturefour-necked flask and was heated
  2. customThereafter, the acetic acid and acetic anhydride were removed by distillation under reduced pressure
  3. washthe residue was washed with water
  4. customdried
  5. customto obtain 24.8 g

出典と根拠

ORDレコード
ord-6c342086942c41dd82b98ef720ab8a93
出典データセット
uspto-grants-1977_02
特許番号
US04009278

反応ノート

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