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Sulfuric Acid → 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-(4,4-Diethoxybutyl)isoindoline-1,3-dione | HCID 12805186 | — |
| 溶媒 | 4,4-Diethoxybutylamine | HCID 80672 | — |
| 生成物 | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
反応手順
Protect the amino function in 4,4-diethoxybutylamine by conversion thereof to a phthalimido function. Hydrolyze the resultant 1-phthalimido-4,4-diethoxybutane with 1N aqueous sulfuric acid at 25° C to obtain 4-phthalimidobutanal. Subject the compound to reductive amination using ammonium chloride and sodium cyanoborohydride in aqueous methanol at 25° C to obtain 4-phthalimidobutylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009328 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-3a306dee696a447e8932b041cbcf69d2 |
| 出典メモ | uspto-grants-1977_02 |