化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Iodide → Potassium Hydroxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Bromocyclobutane | HCID 78110 | — |
| 反応物 | 4-Cyclopropoxybenzoic acid | HCID 21452864 | — |
| 反応物 | Ethyl 4-cyclobutyloxybenzoate | HCID 21452944 | — |
| 反応物 | 2-Ethyl-4-hydroxybenzamide | HCID 21453012 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Potassium Hydroxide | HCID 14797 | 10% |
| 生成物 | 4-Cyclobutoxybenzoic acid | HCID 21452881 | — |
反応手順
The intermediate 4-cyclobutyloxybenzoic acid was prepared following the procedure described in Example 108 for the preparation of the corresponding 4 -cyclopropyloxybenzoic acid using 25 g. of ethyl 4-hydroxybenzamide, 23.1 g. of cyclobutyl bromide, 31 g. of anhydrous potassium carbonate, 2.5 g. of potassium iodide and 300 ml. of dimethylformamide to yield 20.1 g. of ethyl 4-cyclobutyloxybenzoate, which was then hydrolyzed by heating with 200 ml. of 10% aqueous potassium hydroxide solution as in Example 108 to yield 12.7 g. of 4-cyclobutyloxybenzoic acid, m.p. 192°-195° C. after recrystallization from 400 ml. of acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009208 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-412f674b2e844eccb0a5302d1e76cbd2 |
| 出典メモ | uspto-grants-1977_02 |